So you’re craving something tasty but too lazy to spend forever in the kitchen, huh? Same.
Well, grab that apron, because we are about to embark on a delicious journey into comfort food territory. Introducing the Mac and Cheese Meatloaf Casserole—where your classic meatloaf gives a warm hug to everyone’s favorite mac and cheese. It’s like the culinary version of a cozy blanket on a rainy day, minus the guilt… well, maybe just a little guilt. So let’s dive in and whip up this masterpiece together!
Why This Recipe is Awesome
Okay, let’s break it down. This dish is basically a love story between meat and cheese, featuring an all-star supporting cast of macaroni. Sounds pretty epic, right? The beauty of this recipe is that it’s idiot-proof. I mean, if I can pull this off without accidentally burning down my kitchen, then you can too. Cooking should be fun, and this dish makes it feel like a party in the oven. You get the hearty goodness of meatloaf, the gooey richness of cheese, and the satisfying twirl of macaroni all in one glorious casserole. Plus, it’s perfect for leftovers. Your week just got a whole lot better.
Ingredients You’ll Need
Here’s the grocery list before your next shopping trip. Trust me, resist the urge to grab those fancy organic items because we’re going for comfort over sophistication, folks.
- 1 lb ground beef (because what’s meatloaf without beef?)
- 2 cups uncooked macaroni (the more the merrier, right?)
- 2 cups shredded cheddar cheese (the gooier, the better)
- 1/2 cup diced onion (for that savory oomph)
- 1/2 cup breadcrumbs (for texture and crunch)
- 1 large egg (whisk it like you mean it)
- 1/4 cup milk (for the meatloaf because it can’t be dry)
- 2 tbsp butter (for the cheese sauce, because everything’s better with butter)
- 2 cups milk (yes, that’s a lot of milk—welcome to comfort food)
- 1 tsp salt (just a pinch is good)
- 1/2 tsp pepper (because you gotta spice it up)
- 1/2 tsp paprika (adds that boom of flavor)
- 1/2 tsp dry mustard (trust me on this one)
- 2 tbsp flour (for thickening all that cheesy goodness)
Step-by-Step Instructions
Alright, you know the drill. Grab your spatula, and let’s get cooking! Follow these simple steps and watch the magic happen.
- Preheat your oven to 350°F (175°C). You want it nice and cozy in there.
- In a mixing bowl, combine that ground beef, diced onion, breadcrumbs, egg, 1/4 cup of milk, salt, and pepper. Mix it like you mean it. Seriously, channel your inner warrior.
- Press the glorious meat mixture into a greased baking dish. Don’t skimp on greasing; trust me, future you will be grateful.
- Bake the meatloaf for 20 minutes. While it bakes, go ahead and start cooking that macaroni according to the package directions. Once done, drain and set aside.
- For the cheese sauce, melt the butter in a saucepan over medium heat. Stir in the flour and let it cook for one minute. It’s already starting to smell good, right?
- Gradually whisk in the 2 cups of milk until it thickens. Season with salt, pepper, paprika, and dry mustard. Then, stir in the shredded cheese until it is all melty and dreamy.
- Combine the cooked macaroni with the cheese sauce. Pour this cheesy wonder over the meatloaf layer like you just won a cooking competition.
- Top with the remaining cheese because you can never have too much cheese. Bake for an additional 25 minutes or until everything is bubbly and golden brown.
And voilà, you have a casserole that is just begging for a big spoon.

Common Mistakes to Avoid
Now that you are a casserole champion, let’s make sure you don’t commit any of these rookie mistakes.
- Thinking you don’t need to preheat the oven: Trust me, a cold oven is just sad. You gotta give your dish the warmth it deserves right from the start.
- Using low-quality cheese: This is not the time to be frugal. Get that good cheddar which melts beautifully. Your taste buds will thank you.
- Overmixing the meat: You want everything together but not a paste. Think masterpiece, not a meatball smoothie.
- Skipping the greasing: It might sound unnecessary, but burnt edges are for people who like cleaning pans. Don’t be that person.
- Ignoring the resting time: Yes, after your casserole comes out of the oven, let it sit for a few minutes. It needs to gather its thoughts before you go diving in.
Alternatives & Substitutions
Did you run out of something? No worries, I got you covered. Here are some alternatives you can easily swap in without losing your culinary cool:
- Ground beef: Turkey or chicken can work too if you want to pretend it’s a little healthier.
- Macaroni: Any pasta shape you have on hand is fine. Penne or even fusilli will do the trick—let’s keep things interesting.
- Onion: If you’re not a fan, feel free to swap it out for garlic or even shallots. They all add pizzazz.
- Cheddar cheese: Feel free to mix it up. Gouda or mozzarella can be fun twists. Just remember, the cheesier, the better.
- Breadcrumbs: Crushed crackers or panko breadcrumbs are perfect substitutes. Go ahead and get creative.
FAQ (Frequently Asked Questions)
Can I use margarine instead of butter?
Technically yes, but why hurt your soul like that? Butter is where the flavor party begins.
How can I make it vegetarian?
Swap the ground beef for some black beans or lentils, and skip the cheese or use a dairy-free alternative.
Can I prep this ahead of time?
Totally! You can assemble it the day before and just pop it in the oven when you’re ready to dig in.
What if I don’t have an oven-safe dish?
You can always cook it in a regular dish and transfer it to a baking pan halfway through, or just serve it straight from whatever you used. No one’s judging.
Will it still taste good if I use less cheese?
Sure, but don’t come crying to me when you realize you missed out on the magic that is cheese. More cheese equals more happiness.
Can I add veggies?
Absolutely! Throw in some spinach or broccoli for a little green action. Who said comfort food can’t be healthy?
What the heck do I do with leftovers?
You can reheat them, make a sandwich, or throw them in a wrap. Basically, there are no bad choices here.

Final Thoughts
Now go impress someone—or yourself—with your new culinary skills. You’ve just combined two comfort food legends into one delicious casserole. Whether you are chowing down solo or sharing with friends, this dish is sure to give you all the cozy feels. You’ve earned it, so don’t overthink it. Get in that kitchen and show that meatloaf who’s boss. Happy cooking, my friend!
Print
Mac and Cheese Meatloaf Casserole
- Prep Time: 15 minutes
- Cook Time: 45 minutes
- Total Time: 60 minutes
- Yield: 4 servings
- Category: Main Course
- Method: Baking
- Cuisine: American
- Diet: Omnivore
Description
A delicious comfort food that combines classic meatloaf with creamy mac and cheese in a hearty casserole.
Ingredients
- 1 lb ground beef
- 2 cups uncooked macaroni
- 2 cups shredded cheddar cheese
- 1/2 cup diced onion
- 1/2 cup breadcrumbs
- 1 large egg
- 1/4 cup milk
- 2 tbsp butter
- 2 cups milk
- 1 tsp salt
- 1/2 tsp pepper
- 1/2 tsp paprika
- 1/2 tsp dry mustard
- 2 tbsp flour
Instructions
- Preheat your oven to 350°F (175°C).
- In a mixing bowl, combine the ground beef, diced onion, breadcrumbs, egg, 1/4 cup of milk, salt, and pepper. Mix well.
- Press the meat mixture into a greased baking dish.
- Bake the meatloaf for 20 minutes.
- While the meatloaf is baking, cook macaroni according to package directions, then drain and set aside.
- To make the cheese sauce, melt the butter in a saucepan over medium heat. Stir in flour and let cook for one minute.
- Gradually whisk in 2 cups of milk until thickened. Season with salt, pepper, paprika, and dry mustard. Stir in shredded cheese until melted.
- Combine the cooked macaroni with the cheese sauce and pour over the meatloaf.
- Top with the remaining cheese and bake for an additional 25 minutes until bubbly and golden brown.
Notes
Let the casserole sit for a few minutes after baking before serving.
